Memantine may acutely improve cognition and have a mood stabilizing effect in treatment-resistant bipolar disorder.
نویسندگان
چکیده
The patients described in this report used medications that could cause cognitive impairment. Memantine could have antagonized these effects, through unclear mechanisms. To our knowledge, this is the first report on the usefulness of memantine in the treatment of cognitive impairment in bipolar disorder patients. Randomized double-blind controlled studies are needed to validate these preliminary observations.
منابع مشابه
A 10-Week Memantine Treatment in Bipolar Depression: A Case Report. Focus on Depressive Symptomatology, Cognitive Parameters and Quality of Life
Memantine and other glutamatergic agents have been currently investigated in some off-label indications due to glutamatergic involvement in several psychoneurological disorders. We assumed that memantine similarly to ketamine may positively influence mood, moreover having a potential to improve cognition and general quality of life. We report a case of a 49-year-old male hospitalized during a m...
متن کاملAntidepressant-induced Dopamine Receptor Dysregulation: A Valid Animal Model of Manic-Depressive Illness
BACKGROUND Mania seems to be associated with an increased dopamine (DA) transmission. Antidepressant treatments can induce mania in humans and potentiated DA transmission in animals, by sensitizing DA D2 receptors in the mesolimbic system. We have suggested that the sensitization of D2 receptors may be responsible of antidepressant-induced mania. This review aims to report the experimental evid...
متن کاملتوپیرامات و والپروات سدیم همراه با لیتیوم بهعنوان درمان کمکی در اختلال دوقطبی نوجوانان: کارآزمایی بالینی تصادفیشده
AbstractObjectives: In this study the effect of topiramate as adjunctive therapy to lithium on mood disorder in adolescents is compared to that of sodium valproate.Method: In a randomized clinical trial, 30 adolescents with bipolar mood disorder in the manic or mixed phase were treated with either topiramate or sodium valproate. All participants had either not responded adequately to a 4 to 6 w...
متن کاملNonlinear mixed effects evaluation of Hamilton Depression Rating Score following combination treatment of presynaptic- and postsynaptic glutamate receptor inhibitors in bipolar depression patients
Presynapticand postsynaptic glutamatergic modulation is associated with anti-depressant activity that takes several weeks to reach a maximal full effect [1]. Limiting mood elevating effects after single drug administration may be the result of compensatory synaptic processes [2, 3]. Therefore, using augmentation treatment with agents having presynapticand postsynaptic effects on the glutamaterg...
متن کاملDose-Dependent effect of lithium on cognition in mild cognitive impairment.
To the Editor: Miskowiak et al1 showed that recombinant human erythropoietin (rhEPO) has the potential to treat cognitive dysfunction in bipolar disorder patients. Specifically, they found that rhEPO enhanced both sustained attention and speed of complex information processing across learning, attention, and executive function in bipolar disorder patients with moderate to severe cognitive probl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Revista brasileira de psiquiatria
دوره 28 3 شماره
صفحات -
تاریخ انتشار 2006